How AS came to be: 

 

The physician Harry Angelman first delineated the syndrome in 1965, when he described several children in his practice as having "flat heads jerky movements, protruding tongues, and bouts of laughter. 

Most individuals with Angelman syndrome will have severe developmental delays, speech limitations, and motor difficulties. However, individuals with Angelman syndrome can have normal life spans and generally do not show developmental regression as they age. Early diagnosis and tailored interventions and therapies help improve quality of life.